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KMID : 0379520010170000217
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한국독성학회지
2001 Volume.17 No. 0 p.217 ~ p.218
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Mechanism of T-cell Specific Immunosuppression Induced by Prodigiosin
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Kim Hwan-Mook
Park Se-Hyung
Jeon Young-JIn
Lee Sang-Han
Kim Hyoung-Chin
Yang Kyu-Hwan
Han Sang-Bae
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Abstract
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In a series of our screening for immunomodulating substances, we isolated prodigiosin from the culture broth qf Serratia marcescens B-1231. This compound inhibited the T cell-mediated immune responses such as concanavalin A-induced proliferation, mixed lymphocyte response, local graft versus host reaction and T-dependent antibody response at nontoxic concentrations. However. prodigiosin did not effect B cell-mediated immune functions such as lipopolysaccharide-induced proliferation and -activated polyclonal antibody production at the same concentrations. Prodigiosin did not cause death in vitro to lymphocytes at effective concentrations (＜100 nM) and also did not show toxicity in vivo to lymphoid organs at effective dos-ages (10 and 30 mg/kg). The pharmacological potencies were comparable to the activities of well-known T-cell specific immunosuppressants such as cyclosporin A. In our continuing study, mechanism of action of PDG is investigated with respect to the effect of PDG on IL-2/IL-2R pathway and transcription factor.
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KEYWORD
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